Related Experiment Video
Updated: Sep 14, 2025
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Oxygen therapy-related risk factors for aggressive retinopathy of prematurity in low-risk preterm neonates
Hansang Lee1, Jong Rok Oh2, Junwon Lee1
1Department of Ophthalmology, Gangnam Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background:
Aggressive retinopathy of prematurity (A-ROP) poses a significant risk for visual impairment in preterm neonates, including those considered at low risk for ROP. Nonetheless, factors influencing A-ROP occurrence in low-risk preterm neonates remain underexplored. We aimed to identify oxygen therapy-related factors associated with A-ROP in this population.
Methods:
This retrospective case-control study included low-risk preterm neonates (gestational age ≥30 weeks and birth weight ≥1 kg) treated for ROP between January 2005 and May 2023 at two Korean hospitals. Patients were divided into A-ROP and staged ROP groups, and oxygen therapy-related factors were analyzed using logistic regression.
Results:
Of the 99 neonates included, 72% were diagnosed with A-ROP. No significant between-group differences were observed in the total duration of oxygen therapy or its delivery methods, except for non-invasive positive ventilation. Mean partial pressure of oxygen (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.89-0.99) and its fluctuation (OR, 1.09; 95% CI, 1.03-1.15) were significant risk factors for A-ROP, with cutoff values of <52.8% and >82.3%, respectively.
Conclusion:
Maintaining stable oxygen levels while avoiding hypoxia may help reduce the risk for A-ROP in low-risk neonates requiring ROP treatment. These findings may help refine oxygen therapy guidelines in neonatal care to improve A-ROP prevention in this population.
Impact Statement:
Aggressive retinopathy of prematurity (A-ROP) can significantly threaten vision, even in preterm neonates considered at low risk for ROP. The contributing factors to A-ROP in this low-risk population have been insufficiently investigated. This study is the first to identify peripheral oxygen levels and their fluctuations as significant factors associated with A-ROP development in low-risk preterm neonates requiring treatment. These findings highlight the importance of maintaining stable oxygenation and preventing hypoxia to reduce the risk of A-ROP in this population.
Related Concept Videos
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
01:19Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
01:21Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:16Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
01:29Oxygen Requirements and Growth Patterns
01:21Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...