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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Sep 14, 2025

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Risk factor stratification in early-onset primary angle closure disease.

Shikha Gupta1, Suresh Kumar Yadav2, Arnav Panigrahi2

  • 1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. shikhagupta@aiims.edu.

Eye (London, England)
|July 18, 2025
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Summary
This summary is machine-generated.

Early-onset glaucoma is associated with shorter axial length and thicker lenses. Anterior chamber depth and lens thickness are key biometric indicators for identifying glaucoma in young adults with angle closure disease.

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Area of Science:

  • Ophthalmology
  • Biometry
  • Glaucoma Research

Background:

  • Early-onset primary angle closure disease (EOPACD) affects individuals under 40.
  • Understanding biometric factors is crucial for early glaucoma detection in this population.

Purpose of the Study:

  • To identify biometric associations in patients with EOPACD.
  • To determine biometric cut-offs for distinguishing glaucoma from suspects.

Main Methods:

  • Prospective cross-sectional observational study of 190 eyes from 128 patients (aged 20-40).
  • Classified EOPACD into EOPACS, EOPAC, and EOPACG groups.
  • Utilized gonioscopy, ultrasound biomicroscopy, ASOCT, and optical biometry.

Main Results:

  • EOPACG eyes showed shortest axial length (AL), narrowest anterior chamber depth (ACD) and area (ACA).
  • EOPACG eyes had greatest lens vault (LV) and lens thickness (LT).
  • ACD ≤ 2.73 mm, LT ≥ 4.22 mm, and ACA ≤ 17.24 mm² were significant predictors of EOPACG.

Conclusions:

  • Ocular biometric measurements, particularly ACD and LT, are significant in stratifying EOPACD patients.
  • Thickened lens and crowded anterior chamber are prevalent in EOPACG.
  • These findings aid in early glaucoma detection in young adults.