Related Experiment Video

Updated: Sep 14, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

Metabolomic Profiling for Predicting Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease- An

Zahra Amirsardari1,2,3, Ehsan Aghaei Moghadam4,3, Ali Mohebbi5,3

  • 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Cardiovascular Translational Research
|July 18, 2025
PubMed

Insights

This study reveals key metabolic differences in Kawasaki disease (KD) patients, identifying specific metabolites linked to coronary artery aneurysms (CAA) and resistance to intravenous immunoglobulin (IVIG) therapy.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Metabolomics

Background:

  • Kawasaki disease (KD) is a critical pediatric illness.
  • Coronary artery aneurysms (CAA) are a major complication of KD.
  • Resistance to intravenous immunoglobulin (IVIG) therapy impacts KD patient outcomes.

Purpose of the Study:

  • To investigate the metabolomic profile of KD patients.
  • To identify metabolic biomarkers associated with CAA development.
  • To explore metabolic differences in IVIG-resistant versus IVIG-responsive KD patients.

Main Methods:

  • Metabolomic profiling of 26 KD patients using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Analysis of 44 metabolites, including amino acids and acylcarnitines.
  • Pathway analysis utilizing the KEGG database.

Main Results:

  • Methylglutarylcarnitine identified as a differentially expressed metabolite in KD patients with CAA.
  • Specific acylcarnitines (C2, C3, C14, C16, C16OH, C18:2, C18:2OH) differed between IVIG-resistant and responsive groups.
  • Arginine biosynthesis and alanine, aspartate, and glutamate metabolism were significantly affected in KD patients with CAA.

Conclusions:

  • This study identified distinct metabolomic profiles in KD patients with CAA and IVIG resistance.
  • Findings offer novel insights into the metabolic pathways contributing to KD complications.
  • Metabolomic analysis may aid in predicting KD prognosis and treatment response.

Keywords:
Coronary aneurysmCoronary diseaseIntravenous immunoglobulinKawasaki diseaseMetabolitesMetabolomics

More Related Videos

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

610
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
65
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
24
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
58
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
24