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Peripheral origin of plasma dopamine.

S Yoneda, H Tomioka, M Fukuyama

    Japanese Circulation Journal
    |September 1, 1985
    PubMed
    Summary
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    Plasma dopamine originates from peripheral sympathetic nerves, not the kidneys. Studies show kidney removal increases conjugated dopamine, while sympathectomy significantly reduces dopamine levels, confirming its nerve-terminal source.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Physiology

    Background:

    • Plasma catecholamines, including dopamine (DA), play crucial roles in physiological regulation.
    • The precise peripheral origin of circulating dopamine remains incompletely understood.

    Purpose of the Study:

    • To elucidate the peripheral source of plasma dopamine (DA).
    • To investigate the roles of the kidney and sympathetic nervous system in plasma DA regulation.

    Main Methods:

    • Changes in plasma free and conjugated catecholamines were analyzed after specific surgical and chemical interventions.
    • Key procedures included nephrectomy, adrenalectomy, chemical sympathectomy (6-hydroxydopamine), and renal denervation.
    • Immobilization stress was used to assess catecholamine responses.

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    Main Results:

    • Nephrectomy increased conjugated DA, suggesting renal excretion and extra-renal origin.
    • Adrenalectomy eliminated plasma epinephrine but did not affect norepinephrine or DA.
    • Chemical sympathectomy significantly reduced plasma NE and DA levels.
    • Renal denervation did not alter plasma DA levels.

    Conclusions:

    • Plasma dopamine is primarily derived from peripheral sympathetic nerve terminals.
    • The kidney acts as an excretory organ for plasma DA, not a primary source.
    • Renal nerves are not a significant source of circulating dopamine.