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Related Experiment Videos

[Chemosensitivity testing using stem cell assay in urological and other malignancies].

N Yamamoto, H Matuyama, Y Shinohara

    Gan No Rinsho. Japan Journal of Cancer Clinics
    |September 1, 1985
    PubMed
    Summary

    The human tumor stem cell assay successfully grew malignant tumors in vitro, showing potential for predicting chemosensitivity and guiding cancer treatment decisions.

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    Prediction of focal extracapsular extension at radical prostatectomy: Relative merit of transrectal ultrasound, endorectal magnetic resonance imaging, prostate specific antigen, prostate specific antigen density, and systematic biopsy.

    Urologic oncology·2011

    Area of Science:

    • Oncology
    • Cancer Research
    • Stem Cell Biology

    Context:

    • Malignant tumors present a significant challenge in personalized medicine.
    • Accurate prediction of chemosensitivity is crucial for effective cancer treatment.

    Purpose:

    • To evaluate the efficacy of the human tumor stem cell assay in growing various malignant tumors.
    • To assess the in vitro chemosensitivity of tumor cells to specific chemotherapeutic agents.
    • To determine the clinical predictability of in vitro chemosensitivity testing.

    Summary:

    • The human tumor stem cell assay was used to culture 132 primary tumors, with colony formation observed in 49%.
    • In vitro chemosensitivity testing was performed on selected tumors, including uroepithelial, renal, and testicular cancers, against CDDP and interferon.

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  • Clinical correlation studies demonstrated over 60% true positive and 91% true negative predictability for the in vitro chemosensitivity assay.

    • Impact:

    • This assay provides a valuable tool for predicting patient response to chemotherapy.
    • The findings support the use of in vitro chemosensitivity testing for personalized cancer treatment strategies.
    • Improved predictability can lead to more effective therapeutic regimens and better patient outcomes.