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Updated: Sep 14, 2025
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
The Study of Cognitive Functions of Rats with Experimental Alzheimer's Disease after Transplantation of Transduced
E K Karsuntseva1, A D Voronova2, V S Shishkina2
1V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia. katya.karsunceva@gmail.com.
Abstract:
We evaluated the efficiency of transplantation of a gene-cell construct based on olfactory ensheathing cells expressing neurotrophic NGF in female Wistar rats with an experimental model of Alzheimer's disease. NGF improved long-term memory and learning ability in the passive avoidance test at week 3 after cell transplantation.
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