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Updated: Sep 14, 2025

Observing Islet Function and Islet-Immune Cell Interactions in Live Pancreatic Tissue Slices
Published on: April 12, 2021
[Retracted] Inhibition of TLR4 protects rat islets against lipopolysaccharide‑induced dysfunction
Xiao Wang1, Qin Min Ge1, Fan Bian2
1Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China.
Abstract:
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the lower two flow cytometric plots shown in Fig. 3A on p. 809 (namely, the plots for the 'anti‑TLR4+LPS' and 'TLR4‑shRNA+LPS' experiments), these appeared to show similar groupings of dots, which would not have been anticipated if these experiments had been performed discretely under different experimental conditions, suggesting a fundamental flaw either in the way in which these experiments were performed, or in how the results were outputted. The Editor of Molecular Medicine Reports has decided that this paper should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 15: 805‑812, 2017; DOI: 10.3892/mmr.2016.6097].

