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Updated: Sep 14, 2025

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Intensification or de-escalation? What is the standard treatment for human papillomavirus-related oropharyngeal
Pierre Blanchard1, Anne Aupérin2, David Veyer3
1Département de radiothérapie oncologique, Gustave-Roussy, université Paris Saclay, Inserm U1018 Oncostat, Villejuif, France.
Abstract:
The incidence of human papillomavirus-related oropharyngeal cancers has been increasing steadily for several decades. They have a better prognosis than alcohol- and tobacco-related oropharyngeal cancers because they are more sensitive to radiotherapy and chemotherapy and patients have fewer comorbidities. However, some tumours have a high risk of recurrence, for which intensified therapy may be considered. On the other hand, for forms with a good prognosis, numerous therapeutic de-escalation strategies have been considered. The aim of this article is to review the standard of care in 2025, the various de-escalation strategies, the potential benefits of immunotherapy, and the impact of human papillomavirus on surveillance and screening of these cancers.
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