Related Experiment Video
Updated: Sep 14, 2025

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Vitamin K Antagonists Versus Direct Oral Anticoagulation After Transcatheter Mitral Valve Replacement
Maja Wichhart Donzo1, Elsa Hebbo1, Hiroki A Ueyama1
1Structural Heart and Valve Center, Emory University Hospital, Atlanta, Georgia.
None:
Optimal anticoagulation strategies after transcatheter mitral valve replacement (TMVR) remain unknown with no randomized trial data. Current practices for anticoagulation after TMVR vary widely as a result. We aimed to compare clinical outcomes between vitamin K antagonists (VKA) and direct oral anticoagulation (DOAC) after transcatheter mitral valve replacement (TMVR) at our institution. We included consecutive patients who underwent valve in valve (ViV) or valve in ring (ViR) TMVR between 2012 and 2022. Clinical outcomes and valve hemodynamics were compared between VKA and DOAC. Primary outcome was major adverse cardiovascular (MACE), defined as composite of all-cause death, stroke, or valve thrombosis. A total of 148 patients (84 VKA and 64 DOAC) were included. The VKA group had a higher prevalence of myocardial infarction, atrial fibrillation/flutter, and pacemakers. Survival analysis showed no significant difference in cumulative survival free of MACE over 1 year (p = 0.68). Mitral valve mean gradient significantly reduced after intervention (12.9 mmHg to 7.8 mmHg in VKA patients and 10.7 mmHg to 7.5 mmHg in DOAC patients) and was maintained over 1 year without difference between groups (7.6 mmHg and 7.6 mmHg). In conclusion, there was no difference in outcomes between DOAC and VKA after TMVR. Data from randomized clinical trials is still needed to assess efficacy and safety in a larger population.
Related Concept Videos
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis III: Interprofessional Care
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Mitral Stenosis III: Medical Management
Mitral Regurgitation III: Medical Management
Mitral Valve Prolapse II: Assessment and Management

