Related Experiment Video

Updated: Sep 14, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.2K

Nanocarrier drug delivery systems for gynecological cancer therapeutics

Jordan D Berezowitz1, Brittany E Givens1

  • 1Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, United States of America.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 19, 2025
PubMed

Insights

Drug delivery systems (DDS) improve gynecological cancer treatment by enhancing drug bioavailability. Nanocarrier DDS show promise for novel therapies and improving existing treatments, but require further clinical investigation.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Gynecological cancers, originating in various reproductive tissues, often lack early screening, leading to late-stage diagnosis.
  • Drug delivery systems (DDS) are crucial for enhancing chemotherapeutic bioavailability in gynecological cancer treatment.
  • Nanocarrier DDS development focuses on improving current therapies and creating novel treatment strategies.

Purpose of the Study:

  • To review advancements in nanocarrier drug delivery systems for gynecological cancers.
  • To explore the potential of novel materials and polymeric systems in enhancing drug efficacy.
  • To highlight the challenges and future directions for clinical translation of these DDS.

Main Methods:

  • Investigation of metal-based nanoparticles (metals, metal oxides, MOFs) as alternatives to platinum drugs.
  • Evaluation of polymeric delivery systems (dendrimers, nano-/micro-spheres, implants) for improved drug specificity and bioavailability.
  • Review of pre-clinical development focusing on nanocarrier DDS for gynecological malignancies.

Main Results:

  • Nanocarrier DDS can increase the bioavailability of chemotherapeutics for ovarian, endometrial, and cervical cancers.
  • Metal-based nanomaterials offer potential alternatives to traditional platinum-based chemotherapy.
  • Polymeric DDS enhance drug targeting and bioavailability for gynecological tissues.

Conclusions:

  • Advances in nanocarrier DDS significantly enhance therapeutic efficacy for gynecological cancers.
  • Further pre-clinical and clinical investigations are necessary for successful translation of DDS therapies.
  • DDS represent a promising frontier in improving outcomes for gynecological cancer patients.
Keywords:
ChemotherapyExtracellular vesiclesGynecological cancerMetal nanoparticlesPolymeric drug delivery

More Related Videos

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.7K
Manufacture and Drug Delivery Applications of Silk Nanoparticles09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.0K

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
426
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
736
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
851