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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Breaking tolerance: an update of Treg dysfunction in autoimmunity.

Nardos T Cheru1, Yemi Osayame1, Tomokazu S Sumida1

  • 1Yale School of Medicine, 300 George St, New Haven, CT 06511, USA.

Trends in Immunology
|July 19, 2025
PubMed
Summary

FOXP3+ regulatory T cells (Tregs) are crucial for immune tolerance. Their dysfunction drives autoimmune diseases, but understanding Treg instability offers new therapeutic targets for restoring immune balance.

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