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Updated: Sep 14, 2025

Design and Use of a Full Flow Sampling System FFS for the Quantification of Methane Emissions
Published on: June 12, 2016
CT derived fractional flow reserve: Part 1 - Comprehensive review of methodologies
Kashif Shaikh1, Patricia Rodriguez Lozano2, Sotirios Evangelou3
1Department of Medicine, Division of Cardiology, University of Tennessee, Knoxville, TN, USA.
Abstract:
Advancements in cardiac computed tomography angiography (CCTA) have enabled the extraction of physiological data from an anatomy-based imaging modality. This review outlines the key methodologies for deriving fractional flow reserve (FFR) from CCTA, with a focus on two primary methods: 1) computational fluid dynamics-based FFR (CT-FFR) and 2) plaque-derived ischemia assessment using artificial intelligence and quantitative plaque metrics. These techniques have expanded the role of CCTA beyond anatomical assessment, allowing for concurrent evaluation of coronary physiology without the need for invasive testing. This review provides an overview of the principles, workflows, and limitations of each technique and aims to inform on the current state and future direction of non-invasive coronary physiology assessment.
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