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Updated: Sep 14, 2025

Bioprospecting of Extremophilic Microorganisms to Address Environmental Pollution
Published on: December 30, 2021
Mining the gut microbiota for defluorination activity
1Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Abstract:
The gut microbiota harbors a vast array of enzymes, many with unknown functions. In a recent study, Probst et al. mined this ecosystem to identify potential defluorinating enzymes. Combining molecular dynamics, alanine scanning, and machine learning, they uncovered molecular features critical for defluorination enzymatic activity in human gut microbes.
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