Related Experiment Video
Updated: Sep 14, 2025
Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
Serum LH levels before progesterone administration significantly affect pregnancy outcomes in hormone replacement
Xu Han1,2,3,4,5,6,7, Chang Liu1,2,3,4,5,6,7, Jie Wang8,9
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, 157 Jingliu Road, Jinan, 250012, Shandong Province, China.
Background:
In hormone replacement therapy-frozen-thawed embryo transfer (HRT-FET) cycles, endogenous LH levels may still rise, and the relationship between this and pregnancy outcomes is unclear. The purpose of this study was to investigate the correlation between the serum LH levels before progesterone administration in HRT-FET cycles and the live birth rate (LBR).
Methods:
A total of 13 720 HRT-FET cycles were divided into four groups based on serum LH levels according to the quartiles. Meanwhile, subgroup analyses were performed based on the use of pituitary down-regulation to evaluate the independent effects of serum LH levels on pregnancy outcomes. We used multivariate logistic regression analysis to adjust for potential confounding factors.
Results:
In the overall, the 51-75th percentile group showed significant differences in LBR and miscarriage rate compared to the reference group (P = 0.010; P = 0.004), and the > 75th percentile group showed significant difference in biochemical pregnancy rate compared to the reference group (P = 0.022). In the non-pituitary down-regulation group, the 51-75th percentile group and the reference group exhibited significant differences in LBR and miscarriage rate (P = 0.004), and the 26-50th percentile group showed significant difference in miscarriage rate compared to the reference group (P = 0.026). In the pituitary down-regulation group, the > 75th percentile group showed significant difference in biochemical pregnancy rate compared to the reference group (P = 0.045).
Conclusion:
In HRT-FET cycles, low serum LH levels prior to progesterone administration may be associated with poor pregnancy outcomes. For patients presenting with low LH levels, we may recommend deferring the FET cycle to reduce poor pregnancy outcomes.
More Related Videos
08:29Author Spotlight: Multiplex Immunohistochemistry for Understanding Immune Regulation by Uterine NK Cells in Pregnancy
Published on: October 25, 2024
09:35Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts
Published on: March 2, 2017
Related Concept Videos
01:27Ovarian Cycle
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
01:22Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...