Recent advances in surface-modified liposomes with polysaccharides for bioactive delivery

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Food Science

Background:

• Liposomes are common delivery systems but face challenges like low encapsulation efficiency and poor stability.
• Existing liposome limitations hinder effective delivery of bioactive compounds, especially in food applications.
• Surface modification is a key strategy to overcome liposome drawbacks.

Purpose of the Study:

• To review emerging trends in surface-modified liposomes utilizing polysaccharides for bioactive compound delivery.
• To summarize the application of various polysaccharides in liposome surface modification.
• To discuss the potential of these modified liposomes in food applications.

Main Methods:

• Review of scientific literature on polysaccharide-modified liposomes.
• Analysis of different polysaccharides (chitosan, pectin, hyaluronic acid, cellulose, gums) for liposome surface functionalization.
• Discussion of modification strategies, stabilization mechanisms, and food applications.

Main Results:

• Polysaccharides significantly improve liposome stability, encapsulation efficiency, and enable controlled release.
• Chitosan, pectin, hyaluronic acid, cellulose, and gums offer distinct advantages for liposome modification.
• Double-layered liposomes using polysaccharide combinations show promise for enhanced delivery.

Conclusions:

• Surface modification of liposomes with polysaccharides offers a promising strategy to enhance bioactive compound delivery.
• Polysaccharide-modified liposomes present viable solutions for stability and controlled release challenges in food systems.
• Further research into polysaccharide combinations and specific food applications is warranted.