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[Blood serum creatine kinase in diseases of the cardiovascular system]
Insights
Serum creatine-kinase (CK) levels are elevated in many patients with heart conditions like angina and hypertension. High CK activity indicates myocardial ischemia, tachycardia, hypertensive crises, cerebral stroke, and alcoholic cardiopathies.
Area of Science:
- Biochemistry
- Cardiology
- Neurology
Context:
- Investigates serum creatine-kinase (CK) activity in hospitalized patients.
- Focuses on patients with angina pectoris and essential hypertension.
- Examines CK levels in relation to various cardiovascular and neurological conditions.
Purpose:
- To determine the prevalence and significance of elevated serum CK activity in specific patient populations.
- To identify conditions associated with the highest increases in serum CK.
- To assess the impact of intramuscular injections on CK levels.
Summary:
- Serum CK activity was elevated in 40-80% of 632 patients with angina and hypertension.
- Highest CK elevations (4-6 fold) were linked to myocardial ischemia, paroxysmal tachycardia, and hypertensive crises.
- Significantly high CK levels were observed in cerebral stroke (7-fold) and alcoholic cardiopathies (8-fold).
- Intramuscular injections did not correlate with increased CK activation.
Impact:
- Provides insights into the diagnostic utility of serum CK in cardiovascular and neurological emergencies.
- Highlights specific conditions requiring monitoring of CK levels.
- Clarifies that intramuscular injections do not falsely elevate CK in these contexts.
Abstract:
Serum creatine-kinase activity was above the upper normal limit in 40-80% of the 632 patients admitted to hospital for angina pectoris and deteriorating essential hypertension. The highest (4-6-fold) increase over the mean control values was associated with myocardial ischemia, paroxysmal tachycardia and hypertensive crises. Intramuscular injections were shown to be unrelated to increased incidence or magnitude of creatine-kinase activation in the examined patients. Creatine-kinase levels were particularly high in cases of cerebral stroke (a 7-fold increase above normal) and alcoholic cardiopathies (a 8-fold increase).