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Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
Value of contrast-enhanced ultrasound combined with shear wave elastography in differentiating xanthogranulomatous
Junjie Chen1, Caifeng Liu2, Shujie Pang3
1Department of Radiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200438, China; Department of Ultrasound, Shanghai Yida Hospital, Shanghai 201799, China.
Objectives:
To evaluate the value of contrast-enhanced ultrasound (CEUS) combined with two-dimensional shear wave elastography (2D-SWE) in the differential diagnosis of xanthogranulomatous cholecystitis (XGC) and gallbladder carcinoma (GBC).
Methods:
This study included 90 patients who underwent surgical treatment from December 2021 to September 2023. Pathological results divided them into XGC (22 cases) and GBC (68 cases) groups. Both groups underwent 2D, 2D-SWE, and CEUS for the differential diagnosis of XGC and GBC. 2D-SWE assessed the uniformity pattern, margin, and pericholecystic enlargement, while the CEUS analyzed the GB mucosal line, hypo-echoic nodules, vascular imaging types, and enhancement patterns.
Results:
The 2D-SWE assessment revealed that heterogeneity, irregularity, and pericholecystic enlargement were more common in the GBC group than in the XGC group (p < 0.001). Quantitative analysis revealed a significantly higher GB/liver stiffness ratio in GBC than in XGC (p < 0.001). As assessed through CEUS, the XGC group was characterised by synchronised wash-in and slow wash-out (p < 0.001). The GBC group showed 'rapid wash-in and rapid wash-out' mode (p < 0.001). The diagnostic sensitivity, specificity, and accuracy of differentiating XGC lesions from those of GBC using CEUS combined with 2D-SWE were higher than those of either method alone, which were 91.0 %, 90.9 %, and 90.9 %, respectively.
Conclusions:
CEUS combined with 2D-SWE improved the diagnostic efficiency of XGC and GBC, with high sensitivity, specificity, and accuracy.
Clinical Relevance Statement:
CEUS combined with 2D-SWE improved the diagnostic efficiency of XGC and GBC with higher sensitivity, specificity, and accuracy.
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