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Updated: Sep 14, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
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Emerging bioelectronics and optogenetics for neurogastroenterology.

Haitao Liu1, Wenjuan Luo2, Ming Xu3

  • 1General Surgery Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, 310052, China; Zhejiang Key Laboratory of Neonatal Diseases, Hangzhou, 310052, China.

Biosensors & Bioelectronics
|July 20, 2025
PubMed
Summary

Bioelectronics and optogenetics are revolutionizing neurogastroenterology by offering new ways to study and treat enteric nervous system (ENS) disorders like Hirschsprung's disease.

Keywords:
Electrical stimulationEnteric nervous systemGastrointestinal electrophysiologyNeuromodulationOptoelectrical device

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Last Updated: Sep 14, 2025

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Area of Science:

  • Neurogastroenterology
  • Bioengineering
  • Neuroscience

Background:

  • The Enteric Nervous System (ENS) controls gastrointestinal functions.
  • Disruptions in ENS development cause neurogastrointestinal disorders, including Hirschsprung's disease (HSCR).

Purpose of the Study:

  • To review the potential of bioelectronics and optogenetics in neurogastroenterology.
  • To explore applications in understanding, diagnosing, and treating ENS disorders.

Main Methods:

  • Review of current bioelectronic and optogenetic advancements in ENS research.
  • Analysis of electrophysiological characteristics of ENS disorders.
  • Evaluation of bioelectric stimulation for functional deficits.

Main Results:

  • Bioelectronics and optogenetics are accelerating ENS research despite GI tract complexities.
  • These technologies offer novel strategies for ENS disorder management.
  • Optogenetics shows promise for specific ENS studies.

Conclusions:

  • The integration of bioelectronics and optogenetics presents a transformative approach to neurogastroenterology.
  • Translational pathways and challenges for clinical application are being evaluated.
  • These bioengineering innovations hold significant potential for treating ENS-related conditions.