MicroRNA-155 in neurodegeneration

MicroRNA-155 (miR-155) is recognized for its multifaceted roles in neuroinflammation and neurodegeneration. This abstract explores the emerging significance of miR-155, both as an intracellular regulator and encapsulated within exosomes, as a biomarker and therapeutic target in neurodegenerative disorders. Dysregulation of miR-155 is implicated in various conditions, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it modulates key pathways involved in neuronal survival, synaptic plasticity, and immune cell activation. Specifically, miR-155 has been shown to influence microglial activation, cytokine production, and the clearance of protein aggregates, all critical processes in neurodegenerative pathogenesis. Exosomal miR-155, released by various cell types including immune cells and neurons, offers a particularly exciting avenue. These nanovesicles facilitate intercellular communication, delivering their cargo, including miR-155, to recipient cells and influencing their function. As such, exosomal miR-155 levels in biofluids like cerebrospinal fluid and blood are being investigated as potential non-invasive diagnostic and prognostic biomarkers for neurodegenerative diseases. Furthermore, the ability of exosomes to cross the blood-brain barrier makes them attractive vehicles for targeted delivery of therapeutic agents. This review highlights the dual promise of miR-155 and exosomal miR-155: first, as readily measurable indicators of disease progression and response to treatment, and second, as actionable targets for novel therapeutic strategies aimed at modulating neuroinflammation and protecting neuronal integrity.