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Proactive process evaluation of precision medicine platforms: a roadmap.

Kathrin Cresswell1

  • 1Usher Institute, The University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, UK Kathrin.Cresswell@ed.ac.uk.

BMJ Health & Care Informatics
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Summary

Precision medicine offers great potential but faces implementation challenges. A new framework guides the evaluation of precision medicine platforms to ensure their sustainability and manage risks.

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Area of Science:

  • Genomic Medicine
  • Precision Medicine Platforms
  • Health Innovation Ecosystems

Background:

  • Precision medicine holds promise for population health but faces limited practical application due to technological complexity.
  • Current approaches often overlook unintended consequences and lack theory-based frameworks for risk management and sustainability.
  • The integration of precision medicine into healthcare systems requires robust evaluation strategies.

Purpose of the Study:

  • To provide a conceptual overview of evaluation challenges in precision medicine platforms.
  • To propose a theory-informed proactive process evaluation framework for the development and assessment of these platforms.
  • To address the need for systematic evaluation in the rapidly evolving field of precision medicine.

Main Methods:

  • Literature review to identify evaluation challenges.
  • Development of a proactive process evaluation framework based on implementation science.
  • Consideration of infrastructural, socio-organizational, and system-level factors.

Main Results:

  • The proposed framework integrates infrastructural, socio-organizational, and system-level considerations.
  • Key questions are raised regarding platform integration with existing infrastructures and transformation of care pathways.
  • Highlights the need to assess how precision medicine platforms impact care delivery across various settings.

Conclusions:

  • Rapid technological advancements necessitate agile evaluation approaches for precision medicine platforms.
  • Effective evaluation is crucial for navigating market and regulatory challenges.
  • Building a sustainable innovation ecosystem for precision medicine requires proactive and adaptive assessment strategies.