Non-invasive quantitative assessment of urethral compliance in rabbit tubularized incised plate model using...

Low urinary flow rates are frequently observed following tubularized incised plate urethroplasty. The underlying cause is not yet fully understood and may be associated with low urethral compliance. The purpose of this study is to non-invasively evaluate the urethral compliance in a rabbit model. Ten male New Zealand rabbits were randomly divided into a control group and a urethroplasty group for tubularized incised plate urethroplasty. Seven weeks post-operatively, ex vivo urethral compliance was evaluated using both the Jesus invasive measurement and the non-invasive method. The Jesus measurement involved measuring urethral volume and pressure by air insufflation, and the non-invasive method utilized ultrasound and uroflowmetry to assess the urethral anterior-posterior diameter and flow data, respectively. Curve regression analysis was applied to calculate urethral compliance. Curve regression analysis revealed that the median urethral compliance measured by non-invasive method in the control group was 0.247 (0.241, 0.257) mm•s/ml, and it was 0.269 (0.263, 0.270) mm•s/ml in the urethroplasty group, with no significant difference between the two groups. The Jesus method indicated median urethral compliance was 0.141 (0.137, 0.149) ml/cmH₂O for the control group and 0.182 (0.173, 0.192) ml/cmH₂O for the urethroplasty group, showing no significant statistical difference. In the rabbit model, urinary flow rate and anterior-posterior diameter serve as non-invasive indicators that can effectively reflect urethral compliance, and TIP surgery has no significant impact on urethral compliance.