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Area of Science:

  • Pharmacology
  • Public Health
  • Health Economics

Background:

  • Nefopam is a non-opioid analgesic.
  • Increasing prescription of nefopam in contraindicated populations raises concerns about appropriate use.
  • This study evaluates nefopam usage patterns in France, focusing on age, epilepsy, and socioeconomic status.

Purpose of the Study:

  • To analyze the trends and patterns of nefopam utilization in France.
  • To identify if nefopam is being prescribed to contraindicated or vulnerable patient groups.
  • To assess the market share changes of nefopam relative to other analgesics.

Main Methods:

  • Retrospective observational study from January 2016 to December 2022.
  • Utilized data from the French national health insurance information system.
  • Analyzed nefopam dispensing data based on patient demographics (age, epilepsy status) and socioeconomic factors.

Main Results:

  • Nefopam use surged by 121.7% between 2016-2022, increasing its market share to 11.6%.
  • Significant increases in nefopam use were observed in patients under 15 (2.8-fold) and over 65 (1.7-fold).
  • Usage also rose in patients with epilepsy (1.7-fold) and those with disadvantaged socioeconomic status (1.2-fold).

Conclusions:

  • Widespread inappropriate use of nefopam, particularly in contraindicated and vulnerable populations, is evident.
  • The increasing availability of oral nefopam may exacerbate these concerning prescribing patterns.
  • Close national and European monitoring is crucial to manage nefopam use and inform future regulations.