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Aqueous Versus Aerosol Intranasal Corticosteroid Spray for Allergic Rhinitis: Systematic Review and Meta-Analysis
Dylan A Levy1, Ajibola B Bakare2, Robert E Gurevich1
1Department of Otolaryngology, Tulane University School of Medicine, New Orleans, LA, USA.
American Journal of Rhinology & Allergy
|July 21, 2025
Summary
Intranasal corticosteroids (INCs) delivered via aerosol or aqueous sprays show similar efficacy and safety for allergic rhinitis (AR). Patient preference is key for adherence and symptom control in AR treatment.
Area of Science:
- Allergology
- Pharmacology
- Clinical Medicine
Background:
- Allergic rhinitis (AR) significantly impacts global health and economy.
- Intranasal corticosteroids (INCs) are primary treatments for AR.
- Delivery methods include aerosol and aqueous sprays.
Purpose of the Study:
- To compare the efficacy and safety of aerosol versus aqueous INCs for AR.
- To conduct a systematic review and meta-analysis of relevant randomized controlled trials (RCTs).
Main Methods:
- Systematic review and meta-analysis of prospective RCTs.
- Searched four major databases for English-language studies.
- Excluded studies based on predefined criteria to ensure data integrity.
Main Results:
- No significant difference in Total Nasal Symptom Score (TNSS) between delivery methods.
- Aqueous sprays demonstrated a slight advantage in alleviating specific symptoms like congestion and rhinorrhea.
- Adverse events were comparable between aerosol and aqueous INC groups.
Conclusions:
- Aerosol and aqueous INCs exhibit comparable efficacy and safety profiles for AR.
- Individual patient preference is crucial for optimizing treatment adherence and outcomes.
- Choosing between delivery methods should prioritize patient choice for better allergic rhinitis management.
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