Intrahepatic Cholangiocarcinoma With Pulmonary Metastasis in a Rhesus Macaque (Macaca mulatta)
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View abstract on PubMed
Summary
This summary is machine-generated.A Rhesus macaque developed cholangiocarcinoma, a rare liver and lung cancer, which has not been previously documented in captive macaques. This finding highlights the importance of studying spontaneous neoplasia in these animals.
Area Of Science
- Veterinary Pathology
- Primate Oncology
- Comparative Pathology
Background
- Spontaneous neoplasia in non-human primates, particularly Rhesus macaques, requires further investigation.
- Rhesus macaques share age-related tumor incidence patterns with humans, making them valuable models for cancer research.
Purpose Of The Study
- To report a rare case of spontaneous cholangiocarcinoma in a laboratory-kept Rhesus macaque.
- To characterize the histopathological and immunohistochemical features of this neoplasm.
Main Methods
- Necropsy and histopathological examination of liver and lung tissues.
- Immunohistochemical staining for CK7 and Hep-Par1.
Main Results
- A 28-year-old female Rhesus macaque presented with lethargy and inappetence, leading to euthanasia.
- Necropsy revealed multifocal nodules in the liver and lung.
- Histopathology confirmed cholangiocarcinoma, with neoplastic cells positive for CK7 and negative for Hep-Par1.
Conclusions
- This is the first reported case of spontaneous cholangiocarcinoma in a laboratory-kept Rhesus macaque.
- The findings underscore the need for comprehensive understanding of spontaneous tumors in Rhesus macaques for their use in aging and cancer research.
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