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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Ellagic Acid-Zinc Oxide Nanoparticles Show Antioxidant, Antibacterial Activities and Induce Apoptosis in Lung Cancer
Farkhondeh Ghoncheh-Moghadam1, Ahmad Asoodeh1,2, Abbas Vaezi-Kakhki1
1Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Abstract:
Cancer is one of the biggest causes of death in today's world. In the field of cancer treatment, the use of natural compounds has attracted the attention of researchers. A variety of nanoparticles, including zinc oxide nanoparticles, represent a widely utilized therapeutic approach today due to their exceptional biocompatibility and safety profile. In this study, ellagic acid, which is a natural polyphenolic compound, was used together with synthesized zinc oxide nanoparticles. The loading of ellagic acid in zinc oxide nanoparticles was confirmed by FT-IR and XRD methods. Examination of the viability of A549 cancer cells showed that the cytotoxicity of nano drug Ellagic acid-Zno nanoparticle (EAN) is more than that of ellagic acid alone. The percentage of reactive oxygen species (ROS) produced by EAN was higher than that of ellagic acid. Apoptosis was observed in the treated cells by acridine-orange-ethidium-bromide staining. Investigating the cell migration of EAN caused a decrease in cell migration. Based on the research, suggested that EAN can be used as multifunctional nanomedicine nanoparticles.
Insights
This study shows that ellagic acid-zinc oxide nanoparticles (EAN) are more effective at killing cancer cells than ellagic acid alone. EAN also increases reactive oxygen species and reduces cancer cell migration, suggesting its potential as nanomedicine.
Area of Science:
- Nanomedicine
- Cancer Research
- Materials Science
Background:
- Cancer remains a leading global cause of mortality.
- Natural compounds are increasingly explored for cancer treatment.
- Zinc oxide nanoparticles offer biocompatibility and safety for therapeutic applications.
Purpose of the Study:
- To synthesize and characterize ellagic acid-loaded zinc oxide nanoparticles (EAN).
- To evaluate the in vitro efficacy of EAN against A549 cancer cells.
- To investigate the potential of EAN as a multifunctional nanomedicine.
Main Methods:
- Synthesis and characterization of zinc oxide nanoparticles loaded with ellagic acid using FT-IR and XRD.
- Assessment of A549 cancer cell viability and cytotoxicity.
- Measurement of reactive oxygen species (ROS) production.
- Induction of apoptosis via acridine-orange-ethidium-bromide staining.
- Evaluation of cell migration inhibition.
Main Results:
- Successful loading of ellagic acid onto zinc oxide nanoparticles confirmed by FT-IR and XRD.
- EAN exhibited enhanced cytotoxicity against A549 cancer cells compared to ellagic acid alone.
- EAN significantly increased ROS production.
- Apoptosis was induced in treated cancer cells.
- EAN demonstrated a notable decrease in cancer cell migration.
Conclusions:
- Ellagic acid-zinc oxide nanoparticles (EAN) show superior anticancer properties compared to free ellagic acid.
- EAN effectively induces cancer cell death and inhibits migration.
- EAN holds promise as a multifunctional nanomedicine for cancer therapy.
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