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Causal correlation between gut microbiota and stable angina pectoris: a two-sample Mendelian randomisation study
Chengji Zhou1, Jiameng Jia2,3, Yimin Du4
1Emergency Department, Chengdu Second People's Hospital, Chengdu, China.
Acta Cardiologica
|July 21, 2025
Summary
Gut microbiota (GM) imbalance is linked to stable angina pectoris (SAP). This study used Mendelian randomization to confirm a causal link, identifying specific bacteria associated with SAP risk.
Area of Science:
- Genetics
- Microbiology
- Cardiovascular Disease
Background:
- Stable angina pectoris (SAP) is often associated with gut microbiota (GM) imbalance.
- The causal relationship between GM and SAP remains unclear.
Purpose of the Study:
- To investigate the potential causal association between gut microbiota and stable angina pectoris using a two-sample Mendelian randomization approach.
- To identify specific gut bacteria and their genetic functions that may influence SAP risk.
Main Methods:
- Utilized summary data from open genome-wide association studies (GWAS).
- Employed two-sample Mendelian randomization (MR) to assess causality between GM and SAP.
- Performed functional gene enrichment analysis using GWAS data.
Main Results:
- MR analysis revealed a significant positive association between *Ruminococcus* 2 and SAP risk.
- Increased *Ruminococcus* 2 was linked to a 22.3% rise in SAP risk.
- Several other bacterial taxa showed potential positive or negative associations with SAP risk, warranting further investigation.
Conclusions:
- This study provides evidence for a causal relationship between gut microbiota and stable angina pectoris.
- Identifying specific GM and their gene functions may offer novel strategies for SAP prevention and treatment.
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