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Related Experiment Video

Updated: Sep 14, 2025

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

Causal correlation between gut microbiota and stable angina pectoris: a two-sample Mendelian randomisation study.

Chengji Zhou¹, Jiameng Jia^2,3, Yimin Du⁴

¹Emergency Department, Chengdu Second People's Hospital, Chengdu, China.

Acta Cardiologica

|July 21, 2025

Summary

Gut microbiota (GM) imbalance is linked to stable angina pectoris (SAP). This study used Mendelian randomization to confirm a causal link, identifying specific bacteria associated with SAP risk.

Keywords:

Mendelian randomisation causality gut microbiota stable angina pectoris

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Last Updated: Sep 14, 2025

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Genetics
Microbiology
Cardiovascular Disease

Background:

Stable angina pectoris (SAP) is often associated with gut microbiota (GM) imbalance.
The causal relationship between GM and SAP remains unclear.

Purpose of the Study:

To investigate the potential causal association between gut microbiota and stable angina pectoris using a two-sample Mendelian randomization approach.
To identify specific gut bacteria and their genetic functions that may influence SAP risk.

Main Methods:

Utilized summary data from open genome-wide association studies (GWAS).
Employed two-sample Mendelian randomization (MR) to assess causality between GM and SAP.
Performed functional gene enrichment analysis using GWAS data.

Main Results:

MR analysis revealed a significant positive association between *Ruminococcus* 2 and SAP risk.
Increased *Ruminococcus* 2 was linked to a 22.3% rise in SAP risk.
Several other bacterial taxa showed potential positive or negative associations with SAP risk, warranting further investigation.

Conclusions:

This study provides evidence for a causal relationship between gut microbiota and stable angina pectoris.
Identifying specific GM and their gene functions may offer novel strategies for SAP prevention and treatment.