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Concurrent aortic stenosis and hypertension: mortality trends in US older adults from 1999-2020

Ahmed Raza1, Fnu Kalpina2, Manayiel Rehmat3

  • 1Department of Medicine, Services Institute of Medical Sciences, Lahore, Punjab, Pakistan.

Future Cardiology
|July 21, 2025
PubMed

Insights

Mortality from aortic stenosis and hypertension is rising in US older adults, particularly among males and non-Hispanic white individuals. Targeted healthcare interventions are crucial to combat this trend.

Area of Science:

  • Cardiology
  • Public Health
  • Gerontology

Background:

  • Aortic stenosis (AS) is a significant valvular heart disease.
  • Hypertension is a known risk factor that accelerates AS progression, increasing patient morbidity and mortality.
  • Understanding mortality trends in older adults with both conditions is crucial for public health initiatives.

Purpose of the Study:

  • To investigate the mortality trends in US adults aged 65 and older diagnosed with aortic stenosis and hypertension between 1999 and 2020.
  • To identify demographic and geographic disparities in mortality rates within this patient population.

Main Methods:

  • Utilized the CDC WONDER database for comprehensive mortality data.
  • Analyzed age-adjusted mortality rates (AAMRs) per 100,000 individuals.
  • Employed Joinpoint regression to calculate annual percent change (APC) and average APC (AAPC) for trend analysis.

Main Results:

  • A significant increasing mortality trend was observed from 1999 to 2020 (AAPC: 5.51%), with hypertension contributing to 99,250 deaths in AS patients.
  • Males exhibited higher AAMRs (11.51) compared to females (9.99).
  • Non-Hispanic white individuals (11.32) had the highest AAMRs, followed by Hispanic (7.37), Non-Hispanic Black (7.27), and Non-Hispanic Asian (6.12) populations. The West region reported the highest AAMR (13.3), and non-metropolitan areas (11.19) showed higher mortality than metropolitan areas (10.49).

Conclusions:

  • Mortality rates for patients with aortic stenosis and hypertension are increasing, with notable disparities observed across demographic groups (males, non-Hispanic white individuals) and geographic regions (the West).
  • These findings underscore the urgent need for targeted healthcare strategies and interventions to mitigate the rising mortality associated with these co-occurring conditions.
Abstract

Keywords:
Age-adjusted mortality ratesCDC wonder databaseHypertensionMortalityaortic stenosiscardiovascular comorbidities

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