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Related Experiment Videos

Right ventricular function in patients with chronic obstructive pulmonary disease.

H Seibold, E Henze, J Kohler

    Klinische Wochenschrift
    |October 15, 1985
    PubMed
    Summary

    In patients with chronic obstructive pulmonary disease (COPD), right ventricular ejection fraction (RVEF) significantly decreases during exercise. Echocardiography aids in interpreting RVEF in advanced COPD.

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    Area of Science:

    • Cardiology
    • Pulmonology
    • Nuclear Medicine

    Background:

    • Chronic obstructive pulmonary disease (COPD) can affect right ventricular function.
    • Assessing right ventricular ejection fraction (RVEF) is crucial in managing COPD patients.

    Purpose of the Study:

    • To evaluate right ventricular hemodynamics and function in COPD patients during rest and exercise.
    • To determine the relationship between pulmonary pressures and RVEF in COPD.
    • To assess the utility of radionuclide ventriculography and echocardiography in this population.

    Main Methods:

    • Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 COPD patients.
    • Hemodynamic and radionuclide data were collected at rest and during exercise.

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  • Echocardiography was used for interpretation of RVEF.

    • Main Results:

    • Resting RVEF was normal (43.3 +/- 6%), but significantly decreased during exercise (38.8 +/- 6.7%, p < 0.001).
    • Mean pulmonary artery pressures increased significantly from rest (19.9 +/- 3.8 mm Hg) to exercise (41 +/- 9.8 mm Hg, p < 0.001).
    • A linear relationship between pulmonary pressures and RVEF was observed up to 35 mm Hg, with a curvilinear relationship at higher pressures.

    Conclusions:

    • Radionuclide ventriculography is not a substitute for right heart catheterization.
    • Echocardiography is valuable for interpreting RVEF in advanced COPD.
    • Exercise induces significant right ventricular dysfunction in COPD patients.