Related Experiment Video
Updated: Sep 14, 2025
03:47
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
1.1K
Dermatologically Tested Apple-Derived Extracellular Vesicles: Safety, Anti-Aging, and Soothing Benefits for Skin
Lucia Sileo1, Maria Pia Cavaleri1, Luca Lovatti1
1Medical Science Department, University of Ferrara, Ferrara, Italy.
Journal of Cosmetic Dermatology
|July 21, 2025
Summary
Apple-derived vesicles (ADVs) are safe and effective for skin applications. This study confirmed ADVs
Area of Science:
- Plant-derived extracellular vesicles (EVs) research
- Biomaterials for cosmetic and regenerative medicine
- Dermatological applications of natural compounds
Background:
- Extracellular vesicles (EVs) from plant sources, like apple-derived vesicles (ADVs), show promise due to biocompatibility and bioactivity.
- ADVs are being explored for cosmetic, dermatological, and regenerative medicine.
Purpose of the Study:
- To evaluate the safety and efficacy of a 2% ADV-based formulation for topical use.
- To assess the potential of ADVs in skincare and anti-aging treatments.
Main Methods:
- Standardized in vitro safety assays including genotoxicity (Ames test), corneal toxicity, skin irritation, corrosion, and sensitization (OECD guidelines).
- In vivo efficacy assessment over 60 days, measuring skin redness reduction and wrinkle parameters (length, volume, roughness).
Main Results:
- The ADV formulation demonstrated a strong safety profile, showing no genotoxic, cytotoxic, corrosive, or sensitizing effects.
- Significant reduction in skin redness (p < 0.05) and measurable improvements in wrinkle parameters were observed over the 60-day study period.
Conclusions:
- Apple-derived vesicles (ADVs) are confirmed as safe and effective bioactive ingredients for topical applications.
- ADVs show potential for integration into cosmetic and regenerative medicine for enhanced skin health and anti-aging benefits.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
01:15Reticular Dermis
3.0K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
3.0K
01:23Tissue Renewal without Stem Cells
1.8K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
1.8K
01:24Cells of the Epidermis
4.5K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
4.5K
01:21Layers of the Epidermis
4.9K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
4.9K