Recombinant Type III Humanized Collagen Solution for Injection Improves Skin Photoaging in Chinese Population: A Case Series

Lin Tao ¹, Yu Yi ²

⁰Department of Plastic Surgery, Time Plastic Surgery Hospital, Shanghai, China.

Journal of Cosmetic Dermatology +

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July 21, 2025

View abstract on PubMed

Summary

Recombinant type III humanized collagen (RhCol-III) injections effectively improved skin quality in Chinese individuals, enhancing elasticity, firmness, and radiance with no adverse events. This treatment shows promise for anti-photoaging benefits.

Area Of Science

Dermatology
Aesthetic Medicine
Regenerative Medicine

Background

Photoaging causes skin damage like wrinkles and reduced collagen.
Collagen treatments offer skin rejuvenation potential.
Effectiveness of recombinant type III humanized collagen (RhCol-III) in Asian populations requires further study.

Purpose Of The Study

To assess the efficacy of RhCol-III injections for skin rejuvenation in Chinese individuals.
To evaluate improvements in skin quality parameters following RhCol-III treatment.

Main Methods

Eight Chinese participants with photoaging received monthly intradermal RhCol-III injections over 90 days.
Clinical assessments included VISIA imaging, ultrasound, cutometer, and GAIS scores.
Evaluated parameters: elasticity, firmness, wrinkles, pigmentation, and pore size.

Main Results

Significant improvements in skin quality observed, with individual variability.
Enhanced skin tone, radiance, elasticity, and firmness noted.
Increased dermal thickness and density correlated with wrinkle and pore size reduction.

Conclusions

RhCol-III injections are a safe and effective skin rejuvenation treatment.
The solution improved skin elasticity, firmness, tone, and radiance.
RhCol-III shows potential for significant anti-photoaging benefits in Chinese facial skin.

Keywords:

Chinese population photoaging recombinant type III humanized collagen solution skin rejuvenation