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Updated: Jun 23, 2026

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!
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[Two new lignans from Ajania purpurea].

Yu-Shun Cui1, Min Yao1, Xin-Jun DI1

  • 1Jiangxi University of Chinese Medicine Nanchang 330004, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|July 21, 2025
PubMed
Summary

This study isolated 30 compounds from Ajania purpurea, including novel ones, and identified significant anti-inflammatory and anti-ferroptosis activities. These findings highlight the plant

Keywords:
Ajania purpureaanti-inflammatoryferroptosislignan

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacology

Context:

  • Ajania purpurea is a plant species with potential medicinal properties.
  • Comprehensive chemical investigation is crucial for identifying bioactive compounds.
  • Understanding the anti-inflammatory and anti-ferroptosis mechanisms is of therapeutic interest.

Purpose:

  • To isolate and identify chemical constituents from the 70% ethanol extract of Ajania purpurea.
  • To evaluate the isolated compounds for their anti-inflammatory and anti-ferroptosis effects.
  • To elucidate the molecular mechanisms underlying the observed bioactivities.

Summary:

  • Utilized multiple chromatographic techniques (macroporous resin, silica gel, ODS, HPLC) and spectroscopic methods (NMR, MS) to isolate 30 compounds from Ajania purpurea.
  • Identified 13 phenolic acids, 7 coumarins, 2 lignans, 1 flavonoid, 2 sesquiterpenes, 1 steroid, and 4 others, including two new compounds and several compounds new to the Ajania genus.
  • Bioactivity screening revealed significant inhibition of nitric oxide production and demonstrated potential anti-ferroptosis effects of compound 2 by modulating glutathione levels, pro-inflammatory cytokines, and ferroptosis-related proteins and genes.

Impact:

  • Discovery of novel compounds and isolation of previously unreported compounds from Ajania plants.
  • Identification of compounds with significant anti-inflammatory properties.
  • Demonstration of compound 2's potential therapeutic role in mitigating ferroptosis, a form of programmed cell death.