Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motor Units01:13

Motor Units

4.7K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
4.7K
Motor Unit Stimulation01:20

Motor Unit Stimulation

2.0K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone healing and functional outcomes of utilizing contralateral free vascularized fibular graft following en bloc resection of adamantinoma and osteofibrous dysplasia-like adamantinoma.

Journal of pediatric orthopedics. Part B·2026
Same author

Correction: Distinguishing reactive scoliosis: clinical presentation, pathophysiology and a proposed clinical framework.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Long-term health-related quality of life in pediatric ECMO survivors: a prospective controlled study.

Pediatric research·2026
Same author

Burst-Suppression EEG in Early Infantile Developmental and Epileptic Encephalopathies: Phenotype, Genotype, and Outcome.

Neurology·2026
Same author

Comparison of cervical sagittal alignment in normal subjects and adolescents and young adults with idiopathic scoliosis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Related Experiment Video

Updated: Sep 14, 2025

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles
09:07

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles

Published on: September 25, 2015

21.5K

Motor Unit Number Index (MUNIX) in Control Children: Reference Values and Reliability.

Christophe Boulay1,2,3, Emilien Delmont1,4, Frédérique Audic1,5

  • 1Reference Center for Neuromuscular Diseases and ALS Timone University Hospital, Aix-Marseille University, Marseille, France.

Muscle & Nerve
|July 21, 2025
PubMed
Summary

This study establishes reference motor unit number index (MUNIX) values for healthy children, crucial for diagnosing neuromuscular disorders. High intra-investigator reproducibility suggests MUNIX is a reliable biomarker for tracking disease progression and treatment effectiveness.

Keywords:
CMAPMUNIXMUSIXbiomarkercontrol children

More Related Videos

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method
08:25

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method

Published on: June 7, 2018

12.5K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

520

Related Experiment Videos

Last Updated: Sep 14, 2025

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles
09:07

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles

Published on: September 25, 2015

21.5K
CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method
08:25

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method

Published on: June 7, 2018

12.5K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

520

Area of Science:

  • Neurology
  • Electrophysiology
  • Pediatric Medicine

Background:

  • Motor Unit Number Index (MUNIX) is a validated electrophysiological biomarker in adults.
  • Reference values for MUNIX in healthy children are currently lacking.
  • Establishing pediatric reference values is essential for clinical application.

Purpose of the Study:

  • To determine reference MUNIX values in healthy children across different age groups.
  • To assess the reliability of MUNIX measurements in a pediatric population.
  • To provide a basis for using MUNIX in diagnosing and monitoring pediatric neuromuscular conditions.

Main Methods:

  • Sixty healthy children were stratified into four age groups (under 5, 5-10, 10-15, and 15-17 years).
  • MUNIX measurements were conducted in the abductor digiti minimi (ADM) and abductor pollicis brevis (APB) muscles.
  • Measurements were performed by both experienced and inexperienced investigators to assess reproducibility.

Main Results:

  • The abductor pollicis brevis (APB) MUNIX showed significant increases with age, height, and weight (p < 0.001).
  • The APB compound muscle action potential (CMAP) also increased significantly with age, height, and weight (p < 0.001).
  • High intra-investigator reproducibility was observed for the experienced investigator, while inter-investigator reproducibility was lower.

Conclusions:

  • The study successfully established reference MUNIX values for healthy children.
  • High intra-investigator reliability indicates MUNIX's utility as an electrophysiological biomarker in pediatrics.
  • These findings support the use of MUNIX for assessing disease progression and treatment response in pediatric neuromuscular disorders.