Related Experiment Video
Updated: Sep 14, 2025
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Non-muscle invasive bladder cancer in a pregnant patient
Návan van Jaarsveld1, Jeff John1,2
1Division of Urology, Department of Surgery, Frere Hospital and Walter Sisulu University, East London, 5200, South Africa.
Abstract:
Malignant bladder tumors during pregnancy are exceedingly rare and account for less than 2.5 % of all malignancies. NMIBC presents unique diagnostic and management challenges, particularly in balancing maternal and fetal outcomes. We describe a 29-year-old woman diagnosed with NMIBC at 10 weeks' gestation, presenting with macroscopic hematuria. Ultrasonography and MRI confirmed the diagnosis, and TURBT revealed a high-grade T1 NMIBC. Post-operative surveillance and deferred intravesical therapy ensured maternal and fetal safety. The case underscores the challenges in balancing oncological and obstetric outcomes. While TURBT is safe during pregnancy, comprehensive follow-up and post-partum BCG are critical for long-term disease control.
