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Updated: Sep 14, 2025
04:40
Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes
Published on: July 7, 2023
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Intravenous Versus Oral Iron After Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis of Randomized
Mohamed Abuelazm1, Ahmed Fares2, Mohammad Adam3
1Faculty of Medicine Tanta University Tanta Egypt.
Summary
Intravenous (IV) iron repletion improved hemoglobin and ferritin levels and complete response rates in patients with gastrointestinal bleeding (GIB) compared to oral iron. This meta-analysis guides optimal iron supplementation strategies for GIB patients.
Area of Science:
- Gastroenterology
- Hematology
- Clinical Pharmacology
Background:
- Gastrointestinal bleeding (GIB) often necessitates iron repletion.
- Limited comparative data exists for intravenous (IV) versus oral iron for GIB patients.
Purpose of the Study:
- To systematically review and meta-analyze randomized controlled trials (RCTs) comparing IV and oral iron for GIB.
- To guide clinical decisions on iron supplementation in GIB management.
Main Methods:
- Systematic review and meta-analysis of RCTs from major databases (PubMed, Embase, CENTRAL, Scopus, Web of Science).
- Fixed-effects model used for risk ratios (dichotomous) and mean differences (continuous) with 95% confidence intervals.
- PROSPERO registration: CRD42024542759.
Main Results:
- Three RCTs with 254 patients were analyzed.
- IV iron showed significantly higher complete response rates (RR: 1.60) and increased hemoglobin (MD: 1.45 g/dL) and ferritin (MD: 220.02 μg/L) compared to oral iron.
- No significant difference was found in partial response or transferrin saturation.
Conclusions:
- IV iron repletion appears more effective than oral iron for improving hemoglobin and ferritin levels in GIB patients.
- IV iron also demonstrated a higher rate of complete response.
- Further research may solidify consensus on optimal iron supplementation for GIB.
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