Related Experiment Video
Updated: Sep 14, 2025
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Published on: April 30, 2021
Emerging Concepts in Immuno-Oncology: Insights from Natural Language Processing-Driven Co-Occurrence Analysis
Kavita A Iyer1, Rumiana Tenchov1, Julian M Ivanov1
1CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States.
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body's immune system to fight cancer. In this follow-up report, we extend our natural language processing-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this relational analysis, we devised a method to identify terms co-occurring in a single sentence in the title or abstract of >350,000 journal and patent publications. The focus of the current study was on intergroup co-occurrences, namely between therapeutic targets, biomarkers, types of therapy, and types of cancer. In our discussion, we have highlighted potentially emerging co-occurring concept pairs between each of the groups exhibiting rapid growth in publications over the past few years but an overall small number of publications. This analysis provides contextual information that may be useful in directing future research efforts in a valuable direction.
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body's immune system to fight cancer. In this follow-up report, we extend our natural language processing-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this relational analysis, we devised a method to identify terms co-occurring in a single sentence in the title or abstract of >350,000 journal and patent publications. The focus of the current study was on intergroup co-occurrences, namely between therapeutic targets, biomarkers, types of therapy, and types of cancer. In our discussion, we have highlighted potentially emerging co-occurring concept pairs between each of the groups exhibiting rapid growth in publications over the past few years but an overall small number of publications. This analysis provides contextual information that may be useful in directing future research efforts in a valuable direction.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
01:27Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:27Tumor Immunotherapy
02:02Genomics
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...