Related Experiment Video
Updated: Sep 14, 2025
07:46
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Published on: April 30, 2021
4.9K
Emerging Concepts in Immuno-Oncology: Insights from Natural Language Processing-Driven Co-Occurrence Analysis.
Kavita A Iyer1, Rumiana Tenchov1, Julian M Ivanov1
1CAS, A Division of the American Chemical Society, Columbus, Ohio 43210, United States.
ACS Omega
|July 21, 2025
Summary
This study uses natural language processing to analyze over 350,000 publications, identifying emerging immuno-oncology concepts. It highlights co-occurring terms in cancer research to guide future scientific discovery.
Area of Science:
- Oncology
- Immunology
- Bioinformatics
- Computational Biology
Background:
- Immuno-oncology harnesses the immune system to combat cancer.
- Previous analysis identified emerging concepts in immuno-oncology research.
- A follow-up study is needed to contextualize these emerging concepts.
Purpose of the Study:
- To pinpoint the emergence context of previously identified immuno-oncology concepts.
- To perform relational analysis of co-occurring terms in scientific literature.
- To identify rapidly growing but under-published concept pairs in cancer research.
Main Methods:
- Utilized natural language processing (NLP) for literature analysis.
- Developed a method to identify terms co-occurring within single sentences of titles/abstracts.
- Analyzed over 350,000 journal and patent publications.
Main Results:
- Identified intergroup co-occurrences between therapeutic targets, biomarkers, therapy types, and cancer types.
- Highlighted potentially emerging co-occurring concept pairs with rapid publication growth.
- Found concept pairs with high publication growth but a small overall publication count.
Conclusions:
- The relational analysis provides valuable contextual information for immuno-oncology.
- Findings can help direct future research efforts in promising directions.
- Understanding co-occurring concepts aids in navigating the evolving landscape of cancer research.
Related Concept Videos
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
01:27Cytotoxic T Cells-mediated Immune Response
2.2K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
2.2K
02:53Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
01:27Tumor Immunotherapy
664
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
664
02:02Genomics
37.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.5K
02:49Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K