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Updated: Sep 14, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
E‑Liquid and Aerosol Characterization of Popular Disposable E‑Cigarettes
Nicholas E Robertson1, Haylee C Hunsaker2, Megan Yamamoto2
1Department of Environmental Toxicology, University of California Davis, Davis, California 95616, United States.
This study analyzed disposable e-cigarettes, finding nicotine levels often lower than labeled and toxic additives present. Aerosol emissions varied by brand, with Esco Bar producing more harmful carbonyls than Flum Pebble.
Area of Science:
- Analytical Chemistry
- Environmental Health
- Toxicology
Background:
- Disposable e-cigarettes are popular but their e-liquid composition and aerosol emissions are poorly understood.
- Assessing these components is crucial for understanding potential health risks associated with vaping.
Purpose of the Study:
- To investigate the e-liquid composition and aerosol emissions of popular disposable e-cigarette brands.
- To quantify nicotine, organic acids, flavorings, coolants, and carbonyl species in e-liquids and aerosols.
Main Methods:
- Analysis of 25 disposable e-cigarettes from four brands using gas chromatography, mass spectrometry, and liquid chromatography-accurate mass spectrometry.
- Quantification of e-liquid components and aerosol mass formation, including carbonyl species.
Main Results:
- 40% of devices had lower nicotine concentrations than labeled.
- Benzoic acid was prevalent; WS-23 coolant was found in all devices at high concentrations.
- Six additives exceeded toxic thresholds; carbonyl yields varied by brand, with Esco Bar highest and Flum Pebble lowest.
Conclusions:
- Disposable e-cigarette composition and aerosol emissions are complex and vary significantly.
- E-liquid formulation and device design impact harmful carbonyl yields.
- Further research is needed to fully characterize risks associated with vaping these products.
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