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Prognostic Value of Inflammatory Indices in Papillary Gastric Carcinoma with Different Proportions of Papillary Components

  • 0Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, 150081, People's Republic of China.
Journal of Inflammation Research +

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July 21, 2025

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July 21, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Peripheral inflammatory indices like neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammatory index (SII) significantly impact prognosis in advantage papillary gastric carcinoma (APGC) and non-advantage papillary gastric carcinoma (NAPGC). These markers aid in predicting patient outcomes.

Area Of Science

  • Oncology
  • Gastroenterology
  • Inflammation Research

Background

  • Gastric cancer subtypes, including advantage papillary gastric carcinoma (APGC) and non-advantage papillary gastric carcinoma (NAPGC), exhibit distinct clinicopathological features.
  • Peripheral inflammatory indices are increasingly recognized for their potential role in cancer prognostication.

Purpose Of The Study

  • To evaluate the prognostic significance of peripheral inflammatory indices in patients with APGC and NAPGC.
  • To identify independent prognostic factors for each gastric cancer subtype.

Main Methods

  • Retrospective analysis of 270 patients undergoing radical surgery, stratified into APGC (≥50% papillary histology) and NAPGC (<50% papillary histology) cohorts.
  • Assessment of inflammatory indices, clinicopathological characteristics, and survival outcomes using ROC analysis, Kaplan-Meier, Log rank tests, and Cox regression.
  • Development and validation of a nomogram integrating prognostic factors for predictive performance evaluation.

Main Results

  • APGC patients presented with higher pT stage, elevated carcinoembryonic antigen (CEA), and poorer survival compared to NAPGC patients.
  • Neutrophil-to-lymphocyte ratio (NLR) and CEA were independent prognostic factors for APGC.
  • Systemic immune-inflammatory index (SII), age, and pN stage were independent prognostic factors for NAPGC.

Conclusions

  • Distinct clinicopathological characteristics, inflammatory profiles, and prognoses exist between APGC and NAPGC.
  • A nomogram incorporating NLR and SII demonstrates effective prognostic prediction for both APGC and NAPGC patients.

Keywords:

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