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Updated: May 12, 2026
Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
Published on: January 17, 2012
Serum Progranulin as a Potential Diagnostic Predictor in Neonatal Sepsis
Dandan Bei1, Yan Cheng1, Ruoxuan Jiang1
1Department of Neonatology, The Second Hospital of Anhui Medical University, Hefei, CHN.
Background:
The study aimed to evaluate the diagnostic and prognostic power of progranulin (PGRN) in neonatal sepsis.
Methods:
We enrolled 67 newborns hospitalized for sepsis or suspected infection. Serum biomarkers, including PGRN, were quantified at admission. The relationship between PGRN levels and sepsis severity, hospital stay duration, and diagnostic accuracy was analyzed.
Results:
Neonates with sepsis exhibited elevated PGRN concentrations, which correlated directly with prolonged hospitalization. PGRN emerged as a robust prognostic biomarker for neonatal sepsis, indicating the highest predictive power (AUC: 0.956; 95% CI: 0.875-0.991; P < 0.001). At a threshold of 80.4 ng/mL, PGRN achieved 90.91% sensitivity, 80.3% specificity, and an AUC of 0.760.
Conclusion:
This study indicated that PGRN may be an excellent biomarker for early diagnosis and guiding clinical management of neonatal sepsis.
