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The Importance of Blood Inflammatory Parameters in the Assessment of Hemodynamically Significant Coronary Artery

Farhad Arefinia1, Ali Ghaemian2, Maysam Rezapour1

  • 1Department of Paramedical Sciences, Amol School of Paramedicine Sciences, Mazandaran University of Medical Sciences, Sari, Iran.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|July 21, 2025
PubMed

Insights

Inflammation markers like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are linked to coronary artery disease (CAD) severity. Higher NLR and PLR correlate with reduced fractional flow reserve (FFR) in patients with moderate coronary lesions.

Area of Science:

  • Cardiology
  • Immunology
  • Medical Diagnostics

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Inflammation is a key factor in the development and progression of CAD.
  • Blood-based inflammatory markers may offer insights into CAD severity.

Purpose of the Study:

  • To evaluate the association between inflammatory ratios from blood counts and coronary lesion severity in CAD patients.
  • To assess the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) with fractional flow reserve (FFR) measurements.

Main Methods:

  • Retrospective analysis of 97 CAD patients with moderate coronary lesions.
  • Inclusion criteria based on fractional flow reserve (FFR) measurements.
  • Assessment of demographic data, laboratory results, NLR, PLR, and SII stratified by FFR categories.

Main Results:

  • Lower FFR (≤0.80) was associated with significantly higher NLR (P=0.009).
  • Increased NLR and SII correlated with a reduction in FFR (P=0.003).
  • Increased PLR also correlated with a reduction in FFR (P=0.011), though its association with FFR ≤0.80 was not statistically significant (P=0.0948).

Conclusions:

  • Blood inflammatory ratios, particularly NLR, show a significant association with FFR in CAD patients with moderate coronary lesions.
  • These findings suggest a potential role for inflammatory markers in assessing the hemodynamic significance of intermediate coronary stenosis.
  • Further research is warranted to confirm the prognostic value of these markers in guiding clinical decisions for CAD management.

Keywords:
BloodCoronary artery diseaseFractional flow reserveLymphocytesNeutrophilsPlatelet

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