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Updated: Sep 14, 2025
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel
Liying Lu1, Keying Xu1, Huiheng Qu2
1Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Abstract:
The pathogenic factors of inflammatory bowel disease (IBD) are very complex, and further investigation of its pathogenesis is necessary. Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 expressed by intestinal epithelial cells (IEC) can regulate the expression of MHCII in epithelial cells, thus affecting the cross dialogue between IECs and immune cells, and promoting the secretion of IgA by B cells to play a protective function. IgA supplementation can also improve the severe colitis phenotype caused by AF6 loss. Our study provides an understanding of the regulatory mechanisms of the intestinal epithelial expression of MHC II and its important role in colitis, which will aid in treatment and intervention.
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