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Virtual sailing exercise to improve major depressive disorder: A pilot clinical trial protocol
Radietya Alvarabie1, Yang Yun2, Alexandra Gaillard1
1Department of Biomedical, Health and Exercise Sciences, School of Health Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Contemporary Clinical Trials Communications
|July 21, 2025
Summary
This study explores virtual sailing as a novel therapy for Major Depressive Disorder (MDD). Simulated sailing may reduce depression and enhance quality of life in individuals with MDD.
Area of Science:
- Psychiatry
- Neuroscience
- Rehabilitation Medicine
Background:
- Major Depressive Disorder (MDD) significantly impairs quality of life.
- Current non-pharmacological interventions for MDD have limited efficacy.
- Novel therapeutic approaches are needed to manage the burden of MDD.
Purpose of the Study:
- To assess simulated sailing as a novel therapeutic approach for MDD.
- To evaluate the impact of virtual reality-based exercise on depression and quality of life.
- To investigate potential neuroplastic changes associated with virtual sailing in MDD patients.
Main Methods:
- A pilot trial involving 58 adults diagnosed with MDD.
- Participants engaged in 6 weeks of simulated sailing sessions (30 min/week).
- Outcomes measured included depression, anxiety, quality of life, functioning, and neuroimaging (MRI).
Main Results:
- Pilot study findings will guide future therapeutic strategies.
- Virtual sailing is explored as a potential non-pharmacological intervention.
- The study aims to inform new treatments for depression.
Conclusions:
- This pilot study will inform a new therapeutic approach.
- The goal is to reduce depression and improve quality of life for individuals with MDD.
- Virtual sailing shows promise as an innovative treatment for MDD.
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