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Published on: April 18, 2013
The Incidence of Contrast-Induced Nephropathy Following Computed Tomography and Associated Risk Factors
Reza Mosaddegh1, Fatemeh Mohammadi1, Aydin Mohammad Valipour1
1Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Insights
Contrast-induced nephropathy (CIN) affects 8.8% of patients after contrast media imaging. Initial serum creatinine levels were identified as the primary risk factor for developing CIN.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Contrast-induced nephropathy (CIN) is a frequent complication of intravenous contrast media use.
- Identifying CIN incidence and risk factors is crucial for patient safety in medical imaging.
Purpose of the Study:
- To retrospectively determine the incidence of CIN after contrast media administration.
- To identify significant risk factors associated with CIN development.
Main Methods:
- Retrospective cross-sectional study of 160 patients undergoing CT scans with IV contrast.
- Serum creatinine levels measured 48-96 hours post-contrast.
- Analysis of patient demographics, comorbidities, and periprocedural details.
Main Results:
- The incidence of CIN was 8.8% (14 out of 160 patients).
- No significant differences in age or gender between CIN-positive and CIN-negative groups.
- Elevated initial serum creatinine level was the sole significant risk factor for CIN.
Conclusions:
- CIN occurred in 8.8% of the studied patient cohort.
- Initial serum creatinine level is a key predictor for CIN.
- Further research may focus on preventative strategies for high-risk patients.
Abstract:
Introduction: Contrast-induced nephropathy (CIN) is a common adverse effect of imaging using intravenous contrast media. In this study, we aimed to retrospectively investigate the incidence of CIN following contrast media administration and determine the significant risk factor. Methods: This study is a retrospective cross-sectional study conducted in Firoozgar Hospital in Tehran during 2019 to 2020. A total of 160 patients who underwent computed tomography (CT-scan) with IV contrast in the mentioned time period were enrolled in the study. The main dependent variable was serum creatinine level after exposure to contrast which was measured in the following 48-96 h after imaging. Independent variables such as patients' demographics (age and sex), patients' comorbidities (diabetes, hypertension, coronary artery disease, heart failure, peripheral vascular disease, liver failure, and anemia), periprocedural details (hydration procedure, hemoglobin level, hematocrit, serum creatinine level, and glomerular filtration rate prior to exposure to contrast), and patients' drug history were collected by reviewing their medical reports. Results: A total of 14 patients (8.8%) developed CIN, forming the CIN-positive group. The remaining patients, who did not develop CIN, were categorized as the CIN-negative group. There was no statistically significant difference between the two groups in terms of age or gender. Conclusion: 8.8% of patients developed CIN following contrast administration. Among risk factors, the only effectual risk factor was the initial serum creatinine level.
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