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Updated: Sep 14, 2025

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
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Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

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Longitudinal changes in ventricular function and atrioventricular valve failure following cardiac morphology after

Ah Young Kim1, Ji Eun Byun1, Ji Eun Hwang1

  • 1Division of Pediatric Cardiology, Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Journal of Thoracic Disease
|July 21, 2025
PubMed

Insights

Fontan procedure patients experience declining ventricular and atrioventricular valve function over time. Dominant right ventricle, tricuspid valve, and common atrioventricular valve issues predict atrioventricular valve failure.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Long-term outcomes in Fontan patients are linked to ventricular dysfunction and atrioventricular valve (AVV) failure.
  • Limited data exist on longitudinal changes and morphological risk factors for these complications.

Purpose of the Study:

  • To describe longitudinal changes in ventricular function and AVV regurgitation post-Fontan procedure.
  • To identify morphologic risk factors associated with developing ventricular dysfunction and AVV failure.

Main Methods:

  • Retrospective review of echocardiographic images from 174 Fontan patients (1984-2015).
  • Mixed-effects models for serial ejection fraction (EF) and AVV regurgitation analysis.
  • Multivariate logistic regression to identify morphologic risk factors.

Main Results:

  • A significant 6.2% decrease in EF observed over a median follow-up of 17.6 years.
  • Ventricular dysfunction and AVV failure were more prevalent in dominant right ventricle (RV) and two-ventricular (2V) morphologies.
  • Tricuspid valve (TV) and common AVV were significantly correlated with AVV failure.

Conclusions:

  • Fontan patients demonstrate progressive decline in ventricular and AVV function long-term.
  • Dominant RV, TV, and common AVV are prognostic factors for AVV failure.
  • Further research is needed to validate these findings.
Abstract

Keywords:
Fontan operationatrioventricular valve (AVV)echocardiographyfunctional single ventriclelongitudinal study

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