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A Blood Screening Test for Dementia with Lewy Bodies for Primary Care
Melissa Petersen1,2, Tanis J Ferman3, Fan Zhang1,2
1Department of Psychology, Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Introduction:
We sought to cross-validate our previously published blood test for detecting Dementia with Lewy Bodies (DLB).
Method:
Plasma samples were analyzed on 428 individuals (DLB n=89, Parkinson's Disease (PD) without dementia n=126, Alzheimer's Disease (AD) n=108, Normal Controls (NC) n=105).
Results:
The proteomic profile discriminated DLB and PD from NC with an AUC (Area Under the Curve) of 0.96 with demographics of age, sex and education. The proteomic profile also distinguished DLB from the PD group with an AUC of 0.92 with demographics. It further distinguished DLB, PD and AD from NC with an AUC of 0.95 as well as DLB from AD with an AUC of 0.92 with demographics.
Discussion:
This data provides additional evidence of the potential utility of a multi-tiered blood-based proteomic screening method for detecting DLB and distinguishing DLB from NC, PD and AD that can be implemented in primary care settings to aid in the referral process.
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