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Murine Model of Allergen Induced Asthma
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Aerodigestive evaluation in patients with eosinophilic asthma
Chloe Citron1, Jessica Erkman1, Mikhail Kazachkov1
1Department of Pediatrics, Hassenfeld Children's Hospital, NYU Grossman School of Medicine, NYU Langone Health, New York, USA.
Respiratory Medicine Case Reports
|July 21, 2025
Summary
Severe uncontrolled asthma in children may involve eosinophilic inflammation in both the airways and esophagus. Dupilumab treatment improved symptoms and inflammation, highlighting the importance of aerodigestive evaluation for personalized pediatric asthma care.
Area of Science:
- Pediatric Pulmonology
- Gastroenterology
- Allergy and Immunology
Background:
- Severe uncontrolled asthma (SUA) in children presents significant management challenges.
- Eosinophilic airway inflammation is a key phenotype in severe asthma.
- Comorbidities like eosinophilic esophagitis (EoE) can complicate asthma management.
Observation:
- Two pediatric patients with SUA were evaluated using aerodigestive assessment.
- Evaluation revealed concurrent eosinophilic asthma and eosinophilic esophageal inflammation.
- Patients received targeted biological therapy with dupilumab.
Findings:
- Dupilumab treatment led to significant clinical improvement in asthma control.
- Histological examination confirmed a reduction in eosinophilic inflammation.
- Aerodigestive evaluation successfully identified a relevant comorbidity.
Implications:
- Aerodigestive evaluation is crucial for phenotyping pediatric asthma and identifying comorbidities.
- Targeted biological therapies like dupilumab show promise for eosinophilic inflammation in both asthma and EoE.
- Optimizing treatment regimens through comprehensive evaluation can improve outcomes in children with SUA.
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