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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Related Experiment Video

Updated: Sep 14, 2025

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
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Hemoptysis Revealing Microscopic Polyangiitis: A Case Report.

Fatima Zahra Elazizi1,2, Dalal Zagaouch1,2, Soumia Fdil1,2

  • 1Pulmonology Department, Mohammed VI University Hospital, Tangier, MAR.

Cureus
|July 21, 2025
PubMed
Summary
This summary is machine-generated.

Microscopic polyangiitis (MPA), a rare vasculitis, can present with lung and kidney issues. Early diagnosis and treatment with corticosteroids and cyclophosphamide are crucial for managing this ANCA-associated condition.

Keywords:
alveolar hemorrhageanca-associated vasculitisanti-mpo antibodiescyclophosphamidemicroscopic polyangiitispulmonary-renal syndrome

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Area of Science:

  • Nephrology
  • Pulmonology
  • Rheumatology

Background:

  • Microscopic polyangiitis (MPA) is a rare small-vessel vasculitis.
  • It is often associated with anti-neutrophil cytoplasmic antibodies (ANCA), especially anti-myeloperoxidase (MPO).

Observation:

  • A 63-year-old male smoker with hypothyroidism presented with hemoptysis, dyspnea, and constitutional symptoms.
  • Imaging showed bilateral lung infiltrates and pulmonary embolism.
  • Laboratory results revealed anemia, rapidly progressive renal impairment, and high-titer anti-MPO perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA).

Findings:

  • The patient's presentation and serology supported a diagnosis of MPA.
  • Treatment involved high-dose corticosteroids and cyclophosphamide, with dosage adjusted for renal function.

Implications:

  • MPA should be considered in patients with unexplained pulmonary and renal symptoms.
  • Constitutional symptoms and positive ANCA serology are key indicators for suspecting MPA.