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Related Experiment Video

Updated: Sep 14, 2025

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

Ectopic Parathyroid Hormone Expression in Nonmetastatic Prostate Cancer.

Suresh Rama Chandran¹, Yongcheng Benjamin Tan²

¹Department of Endocrinology, Singapore General Hospital, Singapore 169608, Singapore.

JCEM Case Reports

|July 21, 2025

Summary

This study reports a rare case of hyperparathyroidism caused by ectopic parathyroid hormone (PTH) secretion in prostate cancer. Treatment of the cancer resolved the hyperparathyroidism, confirming the link.

Keywords:

ectopic hormone parathyroid hormone prostate cancer

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Area of Science:

Endocrinology
Oncology
Pathology

Background:

Ectopic parathyroid hormone (PTH) secretion is an uncommon cause of hyperparathyroidism.
Prostate cancer, particularly nonmetastatic forms, rarely exhibits ectopic PTH production.

Observation:

A 60-year-old man presented with hyperparathyroidism and hypophosphatemia, with normal calcium levels.
Two years later, he was diagnosed with prostate adenocarcinoma; bone scans excluded metastases.
Elevated urinary calcium excretion was noted, and parathyroid imaging was negative for adenoma.

Findings:

Following successful prostate cancer treatment, both hyperparathyroidism and hypophosphatemia resolved.
Immunostaining of prostate cancer tissue confirmed ectopic PTH expression.
This case identifies ectopic PTH secretion as a cause of hyperparathyroidism in prostate cancer.

Implications:

Recognizing ectopic PTH expression is vital for accurate diagnosis and management of prostate cancer patients with hyperparathyroidism.
This finding expands the differential diagnosis of hyperparathyroidism beyond common causes.
Understanding rare paraneoplastic syndromes is crucial in oncology.