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Lymphocyte-to-Monocyte Ratio and All-Cause Mortality in Populations With Abdominal Aortic Calcification: A
Jingjing Huang1, Chunyong Chen2
1Cardiac Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Insights
Higher lymphocyte-to-monocyte ratio (LMR) is linked to reduced long-term mortality in patients with abdominal aortic calcification (AAC). This finding suggests LMR may serve as a valuable prognostic marker for AAC management.
Area of Science:
- Cardiovascular Research
- Hematology
- Public Health
Background:
- Abdominal aortic calcification (AAC) management requires reliable prognostic markers.
- The lymphocyte-to-monocyte ratio (LMR) is a potential inflammatory biomarker.
Purpose of the Study:
- To investigate the association between LMR and long-term all-cause mortality in adults with AAC.
- To evaluate LMR's predictive capability for mortality risk in the AAC population.
Main Methods:
- Analysis of 888 adults with AAC from NHANES 2013-2014 data.
- Utilized Cox proportional hazards models, Kaplan-Meier curves, and restricted cubic spline analysis.
- Time-dependent ROC analysis assessed predictive ability for survival.
Main Results:
- Higher LMR was significantly associated with reduced all-cause mortality risk (HR=0.72, p=0.02) after covariate adjustment.
- A nonlinear relationship was observed, with risk decreasing below LMR 4.49 (HR=0.49, p<0.0001).
- The area under the curve for 2-, 4-, and 6-year survival ranged from 0.647 to 0.707.
Conclusions:
- Elevated LMR is a significant predictor of lower all-cause mortality in individuals with AAC.
- LMR demonstrates potential as a prognostic biomarker for managing abdominal aortic calcification.
- Further research can explore LMR's role in clinical decision-making for AAC patients.
Abstract:
Objective: The identification of reliable prognostic markers is essential for the effective management of abdominal aortic calcification (AAC). This research focused on assessing whether the lymphocyte-to-monocyte ratio (LMR) correlates with long-term mortality risk in the AAC population. Methods: This analysis included 888 adults with AAC from National Health and Nutrition Examination Survey (NHANES) 2013-2014. Mortality risk was assessed using Cox proportional hazards models and Kaplan-Meier curves. Nonlinear associations between the LMR and mortality were examined with restricted cubic spline (RCS). The predictive ability was evaluated by time-dependent receiver operating characteristic (ROC) analysis. Results: Over median follow-up for 71 months, 145 deaths were recorded. After adjusting for covariates, higher LMR was found to be significantly associated with a reduced risk of all-cause mortality, with a 28% decrease in risk per one-unit increment in LMR (hazard ratio; HR = 0.72, 95% confidence interval (CI): 0.57-0.91, p=0.02). This was consistent across quartiles. A nonlinear relationship was noted; below LMR 4.49, risk decreased (HR = 0.49, 95% CI: 0.40-0.60, p < 0.0001); above it, LMR was not significantly linked to mortality (HR = 1.14, 95% CI: 0.77-1.7, p=0.51). The area under the curve (AUC) for 2-, 4-, and 6-year survival were 0.647, 0.707, and 0.682, respectively. Conclusions: Higher LMR is significantly associated with lower all-cause mortality in individuals with AAC, suggesting its potential utility as a prognostic marker in this population.
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