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Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer

Mehrnaz Mostafavi1, Elham Dehbashi2, Faraz Rahmani Khajeh3

  • 1Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Medical Oncology (Northwood, London, England)
|July 21, 2025
PubMed

Insights

Noncoding RNAs (ncRNAs) interact with the Hippo pathway, influencing colorectal cancer (CRC) progression. This crosstalk offers potential for novel CRC diagnostics and therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) presents a major global health burden.
  • The Hippo pathway is crucial for cellular regulation and implicated in CRC.
  • Dysregulation of the Hippo pathway contributes to CRC initiation, metastasis, and treatment resistance.

Purpose of the Study:

  • To review the mechanistic insights into the crosstalk between noncoding RNAs (ncRNAs) and the Hippo signaling pathway.
  • To highlight the roles of this interaction in colorectal cancer progression, metastasis, and chemoresistance.
  • To emphasize the therapeutic and biomarker potential of ncRNAs in CRC management.

Main Methods:

  • Literature review focusing on ncRNAs (miRNAs, lncRNAs, circRNAs) and their regulation of Hippo pathway components (YAP/TAZ).
  • Analysis of studies investigating the impact of ncRNA-Hippo pathway interactions on CRC.
  • Synthesis of evidence regarding the therapeutic and diagnostic implications of these interactions.

Main Results:

  • ncRNAs dynamically modulate the Hippo pathway, particularly the YAP/TAZ axis.
  • This crosstalk significantly influences colorectal cancer cell proliferation, migration, and survival.
  • Alterations in ncRNA-mediated Hippo pathway regulation are linked to tumor progression and therapy resistance.

Conclusions:

  • The intricate crosstalk between ncRNAs and the Hippo pathway (YAP/TAZ) is a key driver in colorectal cancer.
  • ncRNAs represent promising therapeutic targets and biomarkers for early diagnosis and treatment of CRC.
  • Further research into these interactions can unlock novel strategies for CRC management.
Keywords:
Colorectal cancerHippo signaling pathwayNoncoding RNAsPrognostic biomarkersTumor progressionYAP/TAZ

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